Immunogenetic Bases of Athletes' Adaptation and Prospects for Their Use in Sports Selection
Keywords:
Genotype, athlete's phenotype, immune response, HLA antigen complex, determination, antibody titer, T and B lymphocytes, vaccination.Abstract
Associations with the HLA phenotype, dynamics of T-lymphocytes and B-lymphocytes, antigen-binding lymphocytes (ASL) specifically sensitized to the vaccine antigen, as well as titer increases of specific antibodies were studied in 110 athletes of the Uzbek population with antigenic exposure to typhoid vaccine. It was found that a high level of immune reactivity and antibody production was observed with the HLA-B15 phenotype; a low level of immune response and AT titer was detected with the HLA-B5 and HLA-B35 phenotypes. The immune response to typhoid vaccination with high antibody titer production is associated with an increase in the number of T-lymphocytes and T-helper subpopulation in the blood, the content of ASL and a decrease in B-lymphocytes. High immune reactivity in the HLA-B15 phenotype indicates broad adaptive capabilities, and a low immune response in the HLA-B5 and HLA-B35 phenotypes indicates limited adaptive capabilities of the body, in particular to increased physical exertion.
