Genetic Bases of Hereditary Metabolism Diseases

Abstract

The nature of genotype-environment interactions and their role in the formation of predisposition to pathogenetically independent nosological forms of multifactorial pathology was studied by assessing the joint influence of the studied molecular genetic markers and environmental factors of a toxic nature on the risk of occurrence of the diseases in question. The role of biotransformation enzyme gene polymorphism was studied xenobiotics in the formation of predisposition to the joint development of multifactorial pathology and model intergenic interactions that determine various compatibility.